Aspergillosis - Pathogenesis, clinical manifestations, and therapy

被引:247
作者
Marr, KA
Patterson, T
Denning, D
机构
[1] Fred Hutchinson Canc Res Ctr, Program Infect Dis, Seattle, WA 98109 USA
[2] Univ Texas, Hlth Sci Ctr, Dept Med, San Antonio, TX 78229 USA
[3] N Manchester Grp Hosp, Dept Infect Dis & Trop Med, Manchester M8 6RR, Lancs, England
关键词
D O I
10.1016/S0891-5520(02)00035-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Diseases caused by Aspergillus species are increasing in importance, especially among immunocompromised hosts. Clinical manifestations are variable, ranging from allergic to invasive disease, largely depending on the status of the host's immune system. This article focuses on the pathogenesis and clinical manifestations of diseases caused by Aspergillus species, with more detailed discussion on therapy of the most morbid manifestation, invasive aspergillosis.
引用
收藏
页码:875 / +
页数:21
相关论文
共 124 条
[11]   DETECTION OF ASPERGILLUS SPECIES DNA IN BRONCHOALVEOLAR LAVAGE SAMPLES BY COMPETITIVE PCR [J].
BRETAGNE, S ;
COSTA, JM ;
MARMORATKHUONG, A ;
PORON, F ;
CORDONNIER, C ;
VIDAUD, M ;
FLEURYFEITH, J .
JOURNAL OF CLINICAL MICROBIOLOGY, 1995, 33 (05) :1164-1168
[12]   Increasing volume and changing characteristics of invasive pulmonary aspergillosis on sequential thoracic computed tomography scans in patients with neutropenia [J].
Caillot, D ;
Couaillier, JF ;
Bernard, A ;
Casasnovas, O ;
Denning, DW ;
Mannone, L ;
Lopez, J ;
Couillault, G ;
Piard, F ;
Vagner, O ;
Guy, H .
JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (01) :253-259
[13]   Cloning and disruption of the antigenic catalase gene of Aspergillus fumigatus [J].
Calera, JA ;
Paris, S ;
Monod, M ;
Hamilton, AJ ;
Debeaupuis, JP ;
Diaquin, M ;
LopezMedrano, R ;
Leal, F ;
Latge, JP .
INFECTION AND IMMUNITY, 1997, 65 (11) :4718-4724
[14]   Cytokine- and T helper-dependent lung mucosal immunity in mice with invasive pulmonary aspergillosis [J].
Cenci, E ;
Mencacci, A ;
d'Ostiani, CF ;
Del Sero, G ;
Mosci, P ;
Montagnoli, C ;
Bacci, A ;
Romani, L .
JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (06) :1750-1760
[15]   Th1 and Th2 cytokines in mice with invasive aspergillosis [J].
Cenci, E ;
Perito, S ;
Enssle, KH ;
Mosci, P ;
Latge, JP ;
Romani, L ;
Bistoni, F .
INFECTION AND IMMUNITY, 1997, 65 (02) :564-570
[16]   T cell vaccination in mice with invasive pulmonary aspergillosis [J].
Cenci, E ;
Mencacci, A ;
Bacci, A ;
Bistoni, F ;
Kurup, VP ;
Romani, L .
JOURNAL OF IMMUNOLOGY, 2000, 165 (01) :381-388
[17]  
Chauhan B, 1997, J IMMUNOL, V159, P4072
[18]   Evidence for the involvement of two different MHC class II regions in susceptibility or protection in allergic bronchopulmonary aspergillosis [J].
Chauhan, B ;
Santiago, L ;
Hutcheson, PS ;
Schwartz, HJ ;
Spitznagel, E ;
Castro, M ;
Slavin, RG .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2000, 106 (04) :723-729
[19]   T cell subsets, epitope mapping, and HLA-restriction in patients with allergic bronchopulmonary aspergillosis [J].
Chauhan, B ;
Knutsen, AP ;
Hutcheson, PS ;
Slavin, RG ;
Bellone, CJ .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (10) :2324-2331
[20]   Surgical treatment for pulmonary aspergilloma: a 28 year experience [J].
Chen, JC ;
Chang, YL ;
Luh, SP ;
Lee, JM ;
Lee, YC .
THORAX, 1997, 52 (09) :810-813