2′-deoxy-8-(propyn-1-yl)adenosine-containing oligonucleotides:: Effects on stability of duplex and quadruples structures

被引：19

作者：

Catalanotti, B

Galeone, A

Gomez-Paloma, L

Mayol, L

Pepe, A

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy

[3] Univ Basilicata, Dipartimento Chim, I-85100 Potenza, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(00)00381-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2'-Deoxy-8-(propyn-1-yl)adenosine has been incorporated in synthetic oligodeoxyribonucleotides and its influence on thermal stability of duplex and quadruplex structures investigated by UV, CD and H-1 NMR. The obtained results seem to indicate that the presence of the modified base negatively affects the stability of double stranded DNA whereas remarkably increases the stability of parallel quadruplex structures. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：2005 / 2009

页数：5

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