Evaluating the cytotoxicity of ionic liquids using human cell line HeLa

被引:225
作者
Stepnowski, P
Skladanowski, AC
Ludwiczak, A
Laczynska, E
机构
[1] Univ Gdansk, Fac Chem, PL-80952 Gdansk, Poland
[2] Med Univ Gdansk, Intercollegiate Fac Biotechnol, PL-80211 Gdansk, Poland
[3] Univ Gdansk, PL-80211 Gdansk, Poland
关键词
cytotoxicity; HeLa cell line; ionic liquids; prospective risk assessment;
D O I
10.1191/0960327104ht480oa
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
This paper presents cytotoxicity data of selected imidazolium ionic liquids evaluated in vitro on the human tumor cell line HeLa. It was found that for 1-n-butyl-3-methylimidazolium entities the toxicity depends strongly on the associated anion; EC50 values are lowest for tetrafluoroborate. No direct dependence of the reduced effect concentration was found on elongating the short, methyl chain to ethyl or n-hexyl. Only for the ionic liquid with an n-decyl chain, the longest one studied, did higher hydrophobicity result in a EC50 one order of magnitude lower than that obtained with the n-butyl entity. The effect concentrations of imidazolium ionic liquids in the HeLa system used are lower than the values obtained for conventional organic solvents such as dichloromethane, toluene or xylene.
引用
收藏
页码:513 / 517
页数:5
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