Syntheses of (-)-hygrine and (-)-norhygrine via Wacker oxidation

被引：23

作者：

Majik, Mahesh S. ^{[1
]}

Tilve, Santosh G. ^{[1
]}

机构：

[1] Goa Univ, Dept Chem, Taleigao Plateau 403206, Gao, India

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 21期

关键词：

TROPANE ALKALOIDS; TROPIC ACID; BIOSYNTHESIS; REARRANGEMENT; DISCOVERY; OLEFINS; AMINES;

D O I：

10.1016/j.tetlet.2010.03.098

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hygrine is an important biosynthetic intermediate for tropane alkaloids. A synthesis of (-)-hygrine starting from L-proline is described. The acetonyl side chain of hygrine was fashioned through the Wittig reaction followed by regioselective Wacker oxidation. In addition, this Letter provides the first synthesis of (-)-norhygrine. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2900 / 2902

页数：3

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