Role of the guanidine group in the N-terminal fragment of PTH(1-11)

被引：5

作者：

Caporale, Andrea ^{[1
]}

Woznica, Iwona ^{[2
]}

Schievano, Elisabetta ^{[1
]}

Mammi, Stefano ^{[1
]}

Peggion, Evaristo ^{[1
]}

机构：

[1] Univ Padua, CNR, Inst Biomol Chem, Dept Chem Sci, I-35131 Padua, Italy

[2] Tufts Univ, Sch Med, Dept Physiol, Boston, MA 02111 USA

来源：

AMINO ACIDS | 2010年 / 38卷 / 04期

关键词：

SPPS; CD; Peptidomimetics; PTH; PARATHYROID-HORMONE RECEPTOR; MOLECULAR CHARACTERIZATION; PTH/PTHRP RECEPTOR; BINDING MECHANISM; PEPTIDE; PROTEIN; ANALOGS; CONFORMATION; MINIMIZATION; ANTAGONISTS;

D O I：

10.1007/s00726-009-0337-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A series of PTH hybrids containing a diamine [NH(2)(CH(2)) (n) NH(2); n = 4, 5, 6] in the C-terminal position was synthesized based on the H-Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Har-NH(2) (Har = homoarginine) template. The compounds were pharmacologically characterized at PTH1R receptors for agonist activity.

引用

页码：1269 / 1275

页数：7

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