The heat stable antigen (CD24) is not required for the generation of CD4+ effector and memory T cells by dendritic cells in vivo

被引：10

作者：

de Heusch, M

Garzé, V

Maliszewski, C

Urbain, J

Liu, Y

Moser, M

机构：

[1] Free Univ Brussels, Inst Biol & Med Mol, B-6041 Gosselies, Belgium

[2] Amgen Corp, Seattle, WA 98101 USA

[3] Ohio State Univ, Med Ctr, Dept Pathol, Columbus, OH 43210 USA

[4] Ohio State Univ, Med Ctr, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

IMMUNOLOGY LETTERS | 2004年 / 94卷 / 03期

关键词：

T-cell activation; interferon-gamma; costimulation;

D O I：

10.1016/j.imlet.2004.05.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Previous work has established that CD24 is a costimulatory molecule for T-cell clonal expansion. Studies using CD24-/- mice demonstrated that CD24 plays a critical role in the CD28-independent immune response against virus and soluble antigens. The role of CD24 on dendritic cells (DCs) has not been reported. Here, we compare the CD24(+/+) and CD24(-/-) DCs in the induction of initial clonal expansion and elicitation of memory CD4(+) T cells in vivo. Our results demonstrate that the CD24 expressed on DCs is essential neither for the induction of initial T-cell clonal expansion nor for elicitation of memory activity of primed T cells in vivo. (C) 2004 Elsevier B.V. All rights reserved.

引用

收藏

页码：229 / 237

页数：9

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