Activity of glycopeptides against Staphylococcus aureus infection in a rabbit endocarditis model:: MICs do not predict in vivo efficacy

被引：19

作者：

Asseray, N ^{[1
]}

Jacqueline, C ^{[1
]}

Le Mabecque, V ^{[1
]}

Batard, E ^{[1
]}

Bugnon, D ^{[1
]}

Potel, G ^{[1
]}

Caillon, J ^{[1
]}

机构：

[1] Fac Med, UPRES, EA 3826, Lab Antibiol Clin & Expt, F-44035 Nantes, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 02期

关键词：

D O I：

10.1128/AAC.49.2.857-859.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vivo efficacy of vancomycin and teicoplanin against five Staphylococcus aureus strains with different susceptibilities to them and methicillin was studied. Rabbits were allocated at random to groups for endocarditis induction with one of these five strains and then treated for 2 days with vancomycin or teicoplanin. Each treated group was compared with a control group infected with the same strain. Vancomycin and teicoplanin showed similar activities. Low MICs did not predict better in vivo results.

引用

页码：857 / 859

页数：3

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