National surveillance programme on susceptibility patterns of respiratory pathogens in South Africa: moxifloxacin compared with eight other antimicrobial agents

被引:31
作者
Liebowitz, LD
Slabbert, M
Huisamen, A
机构
[1] Tygerberg Hosp, Dept Med Microbiol, ZA-7505 Tygerberg, South Africa
[2] Univ Stellenbosch, ZA-7505 Tygerberg, South Africa
关键词
D O I
10.1136/jcp.56.5.344
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Aims: The susceptibility patterns of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Klebsiella pneumoniae, and Streptococcus pyogenes isolated from specimens submitted to 12 private laboratories in South Africa were determined. Methods: Minimum inhibitory concentration (MIC) determinations were performed on the isolates in the microbiology laboratory at Tygerberg Hospital according to the recommendations of the National Committee for Clinical Laboratory Standards (NCCLS). Results: According to the NCCLS breakpoints, 24% of 729 S pneumoniae isolates were sensitive, 30% intermediate, and 46% resistant to penicillin. Rates of macrolide resistance were high, with 61 of the pneumococci being resistant to clarithromycin and azithromycin. Co-trimoxazole resistance was also high, with 28% of pneumococcal strains being sensitive, 21% intermediate and 51% resistant. beta Lactamase was produced by 7% of 736 H influenzae isolates and 91% of 256 M catarrhalis isolates. The quinolones, moxifloxacin and levofloxacin, were universally active against all isolates tested, which included S pneumoniae, H influenzae, M catarrhalis, K pneumoniae, and S pyogenes. Conclusions: Haemophilus influenzae and S pneumoniae were the most commonly isolated organisms. Resistance to penicillin was one of the highest reported in the world (76%) in S pneumoniae, as was macrolide resistance in pneumonocci, although surprisingly, only 14% of S pyogenes were resistant. The quinolones, moxifloxacin and levofloxacin were active against all organisms tested, including the penicillin and macrolide resistant strains and moxifloxacin was more active than levofloxacin against pneumococci.
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页码:344 / 347
页数:4
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共 19 条
[1]   Susceptibility of Canadian isolates of Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae to oral antimicrobial agents [J].
Blondeau, JM ;
Vaughan, D ;
Laskowski, R ;
Borsos, S .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2001, 17 (06) :457-464
[2]   Antimicrobial activity of advanced-spectrum fluoroquinolones tested against more than 2000 contemporary bacterial isolates of species causing community-acquired respiratory tract infections in the United States (1999) [J].
Deshpande, LM ;
Jones, RN .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2000, 37 (02) :139-142
[3]   The Alexander Project 1996-1997:: latest susceptibility data from this international study of bacterial pathogens from community-acquired lower respiratory tract infections [J].
Felmingham, D ;
Grüneberg, RN .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 45 (02) :191-203
[4]   Surveillance of resistance in bacteria causing community-acquired respiratory tract infections [J].
Felmingham, D ;
Feldman, C ;
Hryniewicz, W ;
Klugman, K ;
Kohno, S ;
Low, DE ;
Mendes, C ;
Rodloff, AC .
CLINICAL MICROBIOLOGY AND INFECTION, 2002, 8 :12-42
[5]   The drug-resistant pneumococcus - Clinical relevance, therapy, and prevention [J].
Harwell, JI ;
Brown, RB .
CHEST, 2000, 117 (02) :530-541
[6]   Comparative in vitro activity of moxifloxacin against Gram-positive clinical isolates [J].
Hoogkamp-Korstanje, JAA ;
Roelofs-Willemse, J .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 45 (01) :31-39
[7]   Minimizing the impact of drug-resistant Streptococcus pneumoniae (DRSP) - A strategy from the DRSP Working Group [J].
Jernigan, DB ;
Cetron, MS ;
Breiman, RF .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 275 (03) :206-209
[8]   Benchmarking the in vitro activities of moxifloxacin and comparator agents against recent respiratory isolates from 377 medical centers throughout the United States [J].
Jones, ME ;
Staples, AM ;
Critchley, I ;
Thornsberry, C ;
Heinze, P ;
Engler, HD ;
Sahm, DF .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (10) :2645-2652
[9]   Streptococcus pneumoniae respiratory tract infections [J].
Klugman, KP ;
Feldman, C .
CURRENT OPINION IN INFECTIOUS DISEASES, 2001, 14 (02) :173-179
[10]   Comparative in vitro activity of gemifloxacin to other fluoroquinolones and non-quinolone agents against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in the United States in 1999-2000 [J].
Koeth, LM ;
Jacobs, MR ;
Bajaksouzian, S ;
Zilles, A ;
Lin, GR ;
Appelbaum, PC .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2002, 19 (01) :33-37