Mitochondria-targeted antioxidant SkQR1 selectively protects MDR (Pgp 170)-negative cells against oxidative stress

被引：40

作者：

Fetisova, Elena K.

Avetisyan, Armine V.

Izyumov, Denis S.

Korotetskaya, Mariya V.

Chernyak, Boris V.

Skulachev, Vladimir P. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, AN Belozersky Inst Physicochem Biol, Moscow 119991, Russia

来源：

FEBS LETTERS | 2010年 / 584卷 / 03期

基金：

俄罗斯基础研究基金会;

关键词：

Mitochondria-targeted antioxidant; Multidrug resistance; MULTIDRUG-RESISTANCE; PLASTOQUINONE DERIVATIVES; INTERRUPT EXECUTION; TRANSPORTERS; MEMBRANE; COPOLYMERS; TOOLS;

D O I：

10.1016/j.febslet.2009.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A conjugate of plastoquinone with decylrhodamine 19 (SkQR1) selectively accumulates in mitochondria of normal and tumor cells. SkQR1 protected the cellular pool of reduced glutathione under oxidative stress. Overexpression of P-glycoprotein (Pgp 170) multidrug resistance pump strongly suppresses accumulation of SkQR1. The inhibitors of Pgp 170 stimulate accumulation of SkQR1 in various cell lines indicating that SkQR1 is a substrate of Pgp 170. The protective effect of SkQR1 against oxidative stress is diminished in the cells overexpressing Pgp 170. It is suggested that mitochondria-targeted antioxidants could selectively protect normal (Pgp 170-negative) cells against the toxic effect of anti-cancer treatments related to oxidative stress. (C) 2009 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

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收藏

页码：562 / 566

页数：5

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