A small molecule targeting the multifactorial nature of Alzheimer's disease

被引：169

作者：

Cavalli, Andrea

Bolognesi, Maria Laura

Capsoni, Simona

Andrisano, Vincenza

Bartolini, Manuela

Margotti, Elisa

Cattaneo, Antonino

Recanatini, Maurizio

Melchiorre, Carlo

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, Alma Mater Studiorum, I-40126 Bologna, Italy

[2] Lay Line Genom, I-00128 Rome, Italy

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 20期

关键词：

amyloid beta; drug design; neurochemistry; neurodegeneration;

D O I：

10.1002/anie.200700256

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Sights set on a cure: Memoquin (1) affects several mechanisms relevant to Alzheimer's disease (AD): the formation of reactive oxygen species, the processing and aggregation of amyloid β (Aβ) peptides, and acetylcholinesterase activity. In animal models, 1 causes a remarkable decrease in the formation of AD neurodegenerative hallmarks and a significant reversal of behavioral deficits. hAChE, BACE-1, and NQO1 are enzymes targeted by 1. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3689 / 3692

页数：4

共 27 条

[21] Rational approach to discover multipotent anti-Alzheimer drugs [J].