Antioxidant activities of a new lignan and a neolignan from Saururus chinensis

被引：70

作者：

Lee, WS

Baek, YI

Kim, JR

Cho, KH

Sok, DE

Jeong, TS

机构：

[1] Korea Res Inst Biosci & Biotechnol, Natl Res Lab Lipid Metab & Atherosclerosis, Taejon 305333, South Korea

[2] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 22期

关键词：

LDL-antioxidant;

D O I：

10.1016/j.bmcl.2004.08.054

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A new diarylbutane lignan, 2'-hydroxy dihydroguaiaretic acid (4), and a known 8-O-4'-type neolignan, machilin D (5), were isolated from the ethyl acetate extracts of the underground parts of Saururus chinensis. Compounds 4 and 5 exhibited low-density lipoprotein (LDL)-antioxidant activity in the thiobarbituric acid-reactive substances (TBARS) assay (4: IC50 = 3.3 muM and 5: IC50 = 3.8 muM), the lag time of conjugated diene production, the relative electrophoretic mobility (REM) of ox-LDL, the apoB-100 fragmentation on copper-mediated LDL oxidation and the macrophage-mediated LDL oxidation, and radical DPPH scavenging activity. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：5623 / 5628

页数：6

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