Invertebrate lamins

被引：79

作者：

Melcer, Shai

Gruenbaum, Yosef ^{[1
]}

Krohne, Georg

机构：

[1] Hebrew Univ Jerusalem, Inst Life Sci, Dept Genet, IL-91904 Jerusalem, Israel

[2] Bioctr Univ Am Hubland, Div Elect Microscopy, D-97074 Wurzburg, Germany

来源：

EXPERIMENTAL CELL RESEARCH | 2007年 / 313卷 / 10期

基金：

以色列科学基金会;

关键词：

nuclear envelope; nuclear lamina; cell cycle; lamina associated protein;

D O I：

10.1016/j.yexcr.2007.03.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Lamins are the main component of the nuclear lamina and considered to be the ancestors of all intermediate filament proteins. They are localized mainly at the nuclear periphery where they form protein complexes with integral proteins of the nuclear inner membrane, transcriptional regulators, histories and chromatin modifiers. Studying lamins in invertebrate species has unique advantages including the smaller number of lamin genes in the invertebrate genomes and powerful genetic analyses in Caenorkabditis elegans and Drosophila melanogaster. These simpler nuclear lamina systems allow direct analyses of their structure and functions. Here we give an overview of recent advances in the field of invertebrate nuclear lamins with special emphasis on their evolution, assembly and functions. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：2157 / 2166

页数：10

共 94 条

[1] ISOLATION OF NUCLEAR-PORE COMPLEXES IN ASSOCIATION WITH A LAMINA [J].