Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors

被引：25

作者：

Monte, D

Coutte, L

Dewitte, F

Defossez, PA

LeConiat, M

Stehelin, D

Berger, R

deLaunoit, Y

机构：

[1] INST PASTEUR,CNRS URA 1160,UNITE ONCOL MOL,F-59019 LILLE,FRANCE

[2] INST GENET MOLEC,INSERM U301,F-75010 PARIS,FRANCE

来源：

GENOMICS | 1996年 / 35卷 / 01期

关键词：

D O I：

10.1006/geno.1996.0345

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The ERM protein belongs to the family of Ets transcription factors, We show here that the human ERM gene is organized into 14 exons distributed along 65 kb of genomic DNA on chromosome 3. The two main functional domains of ERM, the acidic domain and the DNA-binding ETS domain, are overlapped by three different exons each. The 3'-untranslated region of ERM is 2.1 kb, whereas the 5'-untranslated region is about 0.3 kb; this allows the transcription of ERM transcripts of approximately 4 kb. The human ERM gene is localized to the q27-q29 region of chromosome 3. (C) 1996 Academic Press, Inc.

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页码：236 / 240

页数：5

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