Determination of cinnarizine in pure and pharmaceutical formulations

被引：7

作者：

Devagondanahalli, Manjunatha Hadagali ^{[1
]}

Shaikh, Sarfaraj Mohd Takhi ^{[1
]}

Jaldappagari, Seetharamappa ^{[1
]}

Ramanaboyina, Sudhir Kumar ^{[1
]}

Kasalanti, Harikrishna ^{[1
]}

机构：

[1] Karnatak Univ, Post Grad Dept Studies Chem, Dharwad 580003, Karnataka, India

来源：

JOURNAL OF THE CHINESE CHEMICAL SOCIETY | 2007年 / 54卷 / 01期

关键词：

cinnarizine; spectrophotometric determination; ion-association complex;

D O I：

10.1002/jccs.200700011

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two simple, rapid and sensitive extractive spectrophotometric methods have been developed for the assay of cinnarizine (CNR) in pure and pharmaceutical formulations. The methods are based on the formation of chloroform soluble ion-association complexes of CNR with thymol blue (TB) and with cresol red (CR) in NaOAc-AcOH buffer of pH 3.6 for TB and in KCl-HCl buffer of pH 1.6 for CR with absorption maxima at 405 run and at 403 nm for TB and CR, respectively. Reaction conditions were optimized to obtain the maximum color intensity. The systems obeyed Beer's law in the range of 0.6-15.8 and 0.8-16.6 mu g mL(-1) for TB and CR, respectively. Various analytical parameters have been evaluated and the results have been validated by statistical data.

引用

页码：63 / 68

页数：6

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