Mouse models with modified p53 sequences to study cancer and ageing

被引：14

作者：

Clarke, AR

Hollstein, M

机构：

[1] Cardiff Univ, Cardiff Sch Biosci, Cardiff F10 3US, S Glam, Wales

[2] German Canc Res Ctr, Heidelberg, Germany

来源：

CELL DEATH AND DIFFERENTIATION | 2003年 / 10卷 / 04期

关键词：

transgenic; p53; Cre-Lox; ageing; neoplasia; murine;

D O I：

10.1038/sj.cdd.4401188

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Experiments with p53 transgenic and p53 gene-targeted mouse strains have substantiated, and in some cases challenged, a number of hypotheses on the biology of the p53 protein. New questions have emerged regarding similarities and differences between murine and human genetic networks in various tissues. Mouse models with targeted p53 alleles are now applied not only to investigate tumour susceptibility, but also to address questions pertinent to molecular epidemiology, chemoprevention, development of anticancer p53-specific pharmaceuticals, and ageing.

引用

收藏

页码：443 / 450

页数：8

相关论文

共 78 条

[61] Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53 [J].

Parant, J ;

Chavez-Reyes, A ;

Little, NA ;

Yan, W ;

Reinke, V ;

Jochemsen, AG ;

Lozano, G .

NATURE GENETICS, 2001, 29 (01) :92-95

[62] Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice [J].

Paris, F ;

Fuks, Z ;

Kang, A ;

Capodieci, P ;

Juan, G ;

Ehleiter, D ;

Haimovitz-Friedman, A ;

Cordon-Cardo, C ;

Kolesnick, R .

SCIENCE, 2001, 293 (5528) :293-297

[63] Suppression of Myc-induced apoptosis in β cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression [J].

Pelengaris, S ;

Khan, M ;

Evan, GI .

CELL, 2002, 109 (03) :321-334

[64] Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53 [J].

Pierce, AM ;

Gimenez-Conti, IB ;

Schneider-Broussard, R ;

Martinez, LA ;

Conti, CJ ;

Johnson, DG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) :8858-8863

[65]

PURDIE CA, 1994, ONCOGENE, V9, P603

[66]

Rafferty JA, 1996, ONCOGENE, V12, P693

[67] A SUBSET OF P53-DEFICIENT EMBRYOS EXHIBIT EXENCEPHALY [J].

SAH, VP ;

ATTARDI, LD ;

MULLIGAN, GJ ;

WILLIAMS, BO ;

BRONSON, RT ;

JACKS, T .

NATURE GENETICS, 1995, 10 (02) :175-180

[68] The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice [J].

Sansom, OJ ;

Clarke, AR .

ONCOGENE, 2002, 21 (38) :5934-5939

[69] A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy [J].

Schmitt, CA ;

Fridman, JS ;

Yang, M ;

Lee, S ;

Baranov, E ;

Hoffman, RM ;

Lowe, SW .

CELL, 2002, 109 (03) :335-346

[70] Large-scale analysis of the human and mouse transcriptomes [J].

Su, AI ;

Cooke, MP ;

Ching, KA ;

Hakak, Y ;

Walker, JR ;

Wiltshire, T ;

Orth, AP ;

Vega, RG ;

Sapinoso, LM ;

Moqrich, A ;

Patapoutian, A ;

Hampton, GM ;

Schultz, PG ;

Hogenesch, JB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (07) :4465-4470

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