Although biofuels such as biodiesel and secure, renewable and environmentally safe fuels, their economic viability is a major implementation of biorefineries that products along with biofuels has been to this problem. The biorefinery model would advantageous if the conversion of byproducts streams generated during biofuel production Glycerol-rich streams generated in large biofuels industry, especially during the present an excellent opportunity to establish Once considered a valuable 'co-product', rapidly becoming a 'waste product' with a attributed to it. Given the highly reduced glycerol and the cost advantage of anaerobic fermentative metabolism of glycerol is of review covers the anaerobic fermentation of microbes and the harnessing of this metabolic convert abundant and low-priced glycerol value products, thus creating a path to viability industry. Special attention is given to products