Prodynorphin, proenkephalin and kappa opioid receptor mRNA responses to acute ''binge'' cocaine

被引：63

作者：

Spangler, R

Zhou, Y

Maggos, CE

Schlussman, SD

Ho, A

Kreek, MJ

机构：

[1] Lab. of the Biol. of Addictive Dis., Rockefeller University, New York, NY 10021

来源：

MOLECULAR BRAIN RESEARCH | 1997年 / 44卷 / 01期

关键词：

cocaine; preprodynorphin; preproenkephalin; kappa opioid receptor; mRNA; rat; brain;

D O I：

10.1016/S0169-328X(96)00249-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies showed that preprodynorphin (ppDyn) mRNA increases in caudate-putamen while kappa opioid receptor (KOR) mRNA decreases in substantia nigra after 3 and 14 days ''binge'' cocaine. To further characterize opioid mRNA responses, rats were administered: saline; 1 day cocaine followed by 1 day saline; 1 day cocaine; or 2 days cocaine. ppDyn mRNA in caudate-putamen increased in both groups receiving cocaine on the final day compared to groups receiving saline. Preproenkephalin (ppEnk) mRNA in caudate-putamen increased, and KOR mRNA in substantia nigra decreased, after 2 days of cocaine. Thus ppDyn mRNA is elevated acutely by cocaine, while ppEnk and KOR mRNAs show a significant response only on the second day of ''binge'' cocaine.

引用

页码：139 / 142

页数：4

共 29 条

[1] QUANTITATION OF PREPROENKEPHALIN MESSENGER-RNA LEVELS IN BRAIN-REGIONS FROM MALE FISCHER RATS FOLLOWING CHRONIC COCAINE TREATMENT USING A RECENTLY DEVELOPED SOLUTION HYBRIDIZATION ASSAY [J].