Social transmission of food preference in mice: Methodology and application to galanin-overexpressing transgenic mice

被引：91

作者：

Wrenn, CC ^{[1
]}

Harris, AP ^{[1
]}

Saavedra, MC ^{[1
]}

Crawley, JN ^{[1
]}

机构：

[1] NIMH, Sect Behav Genom, Bethesda, MD 20892 USA

来源：

BEHAVIORAL NEUROSCIENCE | 2003年 / 117卷 / 01期

关键词：

D O I：

10.1037/0735-7044.117.1.21

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Social transmission of food preference (STFP) is a test of olfactory memory that can be used in mice. Confounds in STFP that can lead to misinterpretation of an STFP deficit as a memory impairment include changes in social interaction and olfaction. The issue of changes in social interaction was addressed by evaluating,an observer-centric and a demonstrator-centric method for scoring the interaction phase of STFP in mice. The demonstrator-centric method was applied to a line of STFP-impaired, galanin-overexpressing transgenic (GAL-tg). GAL-tg mice were impaired in STFP without deficits in social interaction. In tests of olfactory ability, GAL-tg mice were unimpaired on buried-food and habituation dishabituation tasks. The current studies describe an expanded method for using STFP in mice and confirm a deficit in olfactory memory in GAL-tg mice.

引用

页码：21 / 31

页数：11

共 89 条

[81] Factors controlling measures of anxiety and responses to novelty in the mouse [J].