RAD51, BRCA2 and DNA repair: a partial resolution

被引：45

作者：

Lord, Christopher J. ^{[1
]}

Ashworth, Alan ^{[1
]}

机构：

[1] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 06期

关键词：

OVARIAN-CANCER; MAINTENANCE; BREAST;

D O I：

10.1038/nsmb0607-461

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cooperation between the DNA recombinase RAD51 and the breast cancer susceptibility protein BRCA2 is crucial for the repair of double-strand DNA breaks. Two papers provide new insight into the BRCA2-RAD51 interaction, revealing two different sets of motifs within BRCA2 that bind structurally distinct forms of RAD51. The balance between these interactions seems to be crucial for the function of BRCA2 in DNA repair.

引用

页码：461 / 462

页数：2

共 9 条

[1] Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats [J].

Davies, Owen Richard ;

Pellegrini, Luca .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (06) :475-483

[2] CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair [J].

Esashi, F ;

Christ, N ;

Gannon, J ;

Liu, YL ;

Hunt, T ;

Jasin, M ;

West, SC .

NATURE, 2005, 434 (7033) :598-604

[3] Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2 [J].

Esashi, Fumiko ;

Galkin, Vitold E. ;

Yu, Xiong ;

Egelman, Edward H. ;

West, Stephen C. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (06) :468-474

[4] Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene [J].

Gayther, SA ;

Mangion, J ;

Russell, P ;

Seal, S ;

Barfoot, R ;

Ponder, BAJ ;

Stratton, MR ;

Easton, D .

NATURE GENETICS, 1997, 15 (01) :103-105

[5] The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability [J].

Gudmundsdottir, K. ;

Ashworth, A. .

ONCOGENE, 2006, 25 (43) :5864-5874

[6] Genome maintenance mechanisms for preventing cancer [J].

Hoeijmakers, JHJ .

NATURE, 2001, 411 (6835) :366-374

[7]

Petalcorin MIR, 2007, P NATL ACAD SCI USA, V104, P8299, DOI [10.1073/pnas.0702805104, 10.1073/pnas.0702808104]

[8] Breast and ovarian cancer [J].

Wooster, R ;

Weber, BL .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (23) :2339-2347

[9] Dynamic control of Rad51 recombinase by self-association and interaction with BRCA2 [J].

Yu, DS ;

Sonoda, E ;

Takeda, S ;

Huang, CLH ;

Pellegrini, L ;

Blundell, TL ;

Venkitaraman, AR .

MOLECULAR CELL, 2003, 12 (04) :1029-1041

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