Multitasking with ubiquitin through multivalent interactions

被引：55

作者：

Liu, Fen ^{[1
]}

Walters, Kylie J. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2010年 / 35卷 / 06期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; LINEAR POLYUBIQUITIN CHAINS; CLATHRIN-COATED PITS; DEUBIQUITINATING ENZYME; DNA-DAMAGE; STRUCTURAL BASIS; LIGASE COMPLEX; PROTEIN UBIQUITINATION; PROTEASOME INHIBITION; CONJUGATING ENZYMES;

D O I：

10.1016/j.tibs.2010.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ubiquitylation - the post-translational modification of proteins with ubiquitin - serves powerful regulatory roles in eukaryotes. It can label proteins for destruction or activate gene transcription. Despite its versatility, ubiquitin is used to signal for cellular events with exquisite specificity. To achieve both versatility and specificity, ubiquitin signaling pathways use multivalency, namely the coordinated use of multiple interaction surfaces. Multivalent interactions regulate each stage of ubiquitin signaling pathways, and appear within the ubiquitin signal, the ubiquitylated substrate, ubiquitin processing enzymes and ubiquitin recognition proteins.

引用

页码：352 / 360

页数：9

共 100 条

[1] Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase [J].

Cadwell, K ;

Coscoy, L .

SCIENCE, 2005, 309 (5731) :127-130

[2] Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability [J].

Chandrasekharan, Mahesh B. ;

Huang, Fu ;

Sun, Zu-Wen .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (39) :16686-16691

[3] UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation [J].

Chen, XA ;

Zhang, Y ;

Douglas, L ;

Zhou, PB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (51) :48175-48182

[4] ATM activates p53 by regulating MDM2 oligomerization and E3 processivity [J].

Cheng, Qian ;

Chen, Lihong ;

Li, Zhenyu ;

Lane, William S. ;

Chen, Jiandong .

EMBO JOURNAL, 2009, 28 (24) :3857-3867

[5] N-terminal ubiquitination: more protein substrates join in [J].

Ciechanover, A ;

Ben-Saadon, R .

TRENDS IN CELL BIOLOGY, 2004, 14 (03) :103-106

[6] Gly-Ala Repeats Induce Position-and Substrate-specific Regulation of 26 S Proteasome-dependent Partial Processing [J].

Daskalogianni, Chrysoula ;

Apcher, Sebastien ;

Candeias, Marco M. ;

Naski, Nadia ;

Calvo, Fabien ;

Fahraeus, Robin .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (44) :30090-30100

[7] RING Domain E3 Ubiquitin Ligases [J].

Deshaies, Raymond J. ;

Joazeiro, Claudio A. P. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2009, 78 :399-434

[8] Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover [J].

Dias, Sylvia S. ;

Hogan, Carol ;

Ochocka, Anna-Maria ;

Meek, David W. .

FEBS LETTERS, 2009, 583 (22) :3543-3548

[9] Ubiquitin-binding domains - from structures to functions [J].

Dikic, Ivan ;

Wakatsuki, Soichi ;

Walters, Kylie J. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (10) :659-671

[10] Epsin binds to clathrin by associating directly with the clathrin-terminal domain - Evidence for cooperative binding through two discrete sites [J].

Drake, MT ;

Downs, MA ;

Traub, LM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (09) :6479-6489

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