Trypanosoma cruzi clonal diversity and the epidemiology of Chagas' disease

被引：89

作者：

Buscaglia, CA

Di Noia, JM

机构：

[1] NYU, Sch Med, Dept Pathol, Michael Heidelberger Div Immunol, New York, NY 10016 USA

[2] MRC, Mol Biol Lab, PNAC Unit, Cambridge CB2 2QH, England

来源：

MICROBES AND INFECTION | 2003年 / 5卷 / 05期

关键词：

Trypanosoma cruzi; Chagas' disease; clonality; epidemiology; TSSA;

D O I：

10.1016/S1286-4579(03)00050-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chagas' disease is caused by the protozoan Trypanosoma cruzi and it has a variable clinical outcome. The basis for this variability relies in part on the complexity of the parasite population consisting of multiple clones displaying distinct biological properties. A major current challenge is to correlate parasite genetic variability with pathogenesis. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：419 / 427

页数：9

共 47 条

[41] Impact of Trypanosoma cruzi clonal evolution on its biological properties in mice [J].