Progress in targeting bacterial transcription

被引：72

作者：

Villain-Guillot, Philippe

Bastide, Lionel

Gualtieri, Maxime

Leonetti, Jean-Paul

机构：

[1] Ctr Etud Agents Pathogenes & Biotechnol Sante, CNRS, UMR 5236, UM1 UM2, F-34093 Montpellier, France

[2] Slectbiotics, F-30000 Nimes, France

来源：

DRUG DISCOVERY TODAY | 2007年 / 12卷 / 5-6期

关键词：

D O I：

10.1016/j.drudis.2007.01.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The bacterial RNA polymerase (RNAP) is an essential enzyme that is responsible for making RNA from a DNA template and is targeted by several antibiotics. Rifampicin was the first of such antibiotics to be described and is one of the most efficient anti-tuberculosis drugs in use. In the past five years, structural studies of bacterial RNAP and the resolution of several complexes of drugs bound to RNAP subunits have revealed molecular details of the drug-binding sites and the mechanism of drug action. This knowledge opens avenues for the development of antibiotics. Here these drugs are reviewed, together with their mechanisms and their potential interest for therapeutic applications.

引用

页码：200 / 208

页数：9

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