Synthesis of thiazolone-based sulfonamides as inhibitors of HCVNS5B polymerase

被引：34

作者：

Ding, Yili ^{[1
]}

Smith, Kenneth L. ^{[1
]}

Varaprasad, Chamakura V. N. S. ^{[1
]}

Chang, Eugene ^{[1
]}

Alexander, John ^{[1
]}

Yao, Nanhua ^{[1
]}

机构：

[1] Valeant Pharmaceut Int, Res & Dev, Drug Discovery, Costa Mesa, CA 92626 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 03期

关键词：

HCV; NS5B ploymerase inhibitor; synthesis;

D O I：

10.1016/j.bmcl.2006.08.104

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several thiazolone-based sulfonamides were prepared, utilizing various hetero-aryl sulfonyl chlorides and different aldehydes, as inhibitors of NS5B polymerase, to target HCV. The best compound showed 0.6 nM Of IC50 inhibitory activity. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：841 / 845

页数：5

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