Limited diversity of HLA-DRB1*02 alleles and DRB1-DRB5 haplotype associations in four United States population groups

被引：9

作者：

Baldassarre, LA

Steiner, NK

Jones, P

Tang, T

Slack, R

Ng, J

Hartzman, RJ

Hurley, CK

机构：

[1] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20057 USA

[2] Georgetown Univ, Dept Pediat, Washington, DC 20057 USA

[3] Naval Med Res Ctr, Kensington, MD USA

来源：

TISSUE ANTIGENS | 2003年 / 61卷 / 03期

关键词：

allele frequency; haplotypes; HLA-DR;

D O I：

10.1034/j.1399-0039.2003.00018.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

At least 60 DRB1*02 positive individuals from each of four US population groups found within a hematopoietic stem cell volunteer donor registry - Caucasoids, African Americans, Asians/Pacific Islanders, and Hispanics - were randomly selected from a database of 82,979 individuals. DRB1*02 alleles were identified by DNA sequencing. A total of five of 23 known DRB1*02 alleles were detected. DRB1*15011 was the predominant DRB1*02 allele in Caucasoids and Hispanics. The most common DRB1*02 allele observed in African Americans was DRB1*1503, and DRB1*15021 in Asians/Pacific Islanders. Caucasoids were found to be the least diversified; only DRB1*15011 and DRB1*16011 were observed. A subset of individuals was also typed for DRB5 alleles by DNA sequencing. DRB5*01011, DRB5*0102, DRB5*0103, DRB5*0108N and DRB5*0202 were detected and nine DRB1-DRB5 haplotypes defined.

引用

页码：249 / 252

页数：4

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