Mechanism of capsaicin inhibition of aldose reductase activity

被引：19

作者：

Alim, Zuhal ^{[1
]}

Kilinc, Namik ^{[2
]}

Sengul, Bulent ^{[3
]}

Beydemir, Sukru ^{[4
,5
]}

机构：

[1] Ahi Evran Univ, Fac Sci & Arts, Dept Chem, TR-40000 Kirsehir, Turkey

[2] Igdir Univ, Vocat Sch Hlth Serv, Dept Med Serv & Tech, TR-76000 Igdir, Turkey

[3] Bayburt Univ, Vocat Sch Hlth Serv, Dept Hlth Care Serv, TR-69000 Bayburt, Turkey

[4] Ataturk Univ, Dept Chem, Fac Sci, TR-25240 Erzurum, Turkey

[5] Anadolu Univ, Dept Biochem, Fac Pharm, TR-26470 Eskisehir, Turkey

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2017年 / 31卷 / 07期

关键词：

aldose reductase; capsaicin; diabetic complications; inhibition; DIABETIC COMPLICATIONS; PHENOLIC-COMPOUNDS; ELLAGIC ACID; IDENTIFICATION; PREVENTION; MICE;

D O I：

10.1002/jbt.21898

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Aldose reductase (AR) inhibitors play a vital importance as a potential therapeutic and preventive medicine when it comes to hyperglycemia associated diabetic complications. Additionally, capsaicin is used as a food additive and a drug in a number of diverse clinical trials. The aim of this study is to determine the in vitro inhibition behavior of capsaicin on AR enzyme activity, which was obtained from different rat tissues (heart, kidney, liver, and brain). We showed that AR was inhibited by capsaicin in the micromolar range and noncompetitive manner in all of the tissues. K-i values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR. In conclusion, capsaicin may be an effective molecule when used in low concentrations to prevent diabetic complications associated with the polyol pathway.

引用

页数：5

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