Bioinorganic chemistry of bismuth and antimony: Target sites of metallodrugs

被引：177

作者：

Ge, Ruiguang

Sun, Hongzhe ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Open Lab Chem Biol, Hong Kong, Hong Kong, Peoples R China

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2007年 / 40卷 / 04期

关键词：

D O I：

10.1021/ar600001b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The biocoordination chemistry of antimony and bismuth has been extensively investigated due to the historical use of these metals in medicine. Structures of bismuth antiulcer agents and interactions of Bi3+ with proteins and enzymes, such as transferrin and lactoferrin, the histidine-rich protein Hpn, and urease, have been characterized. Sb5+ is a prodrug and is bioreduced or activated to its active form Sb3+ intracellularly. Antimony binds to biomolecules, such as glutathione, trypanothione, and nucleotides, and forms binary and ternary complexes, which may allow it to be trafficked in cells. These studies have improved our understanding of the mechanism of action of bismuth and antimony drugs, which in turn allows the future design of drugs.

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页码：267 / 274

页数：8

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