The Philadelphia chromosome as a secondary change in leukemia: Three case reports and an overview of the literature

被引：13

作者：

Chen, Z

Morgan, R

Notohamiprodjo, M

Meloni-Ehrig, A

Schuster, RT

Bennett, JS

Cohen, JD

Stone, JF

Sandberg, AA

机构：

[1] Genzyme Genet, Scottsdale, AZ USA

[2] Paoli Mem Hosp, Paoli, PA USA

[3] Pediat Hematol Oncol Associates, Phoenix, AZ USA

来源：

CANCER GENETICS AND CYTOGENETICS | 1998年 / 101卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(97)00262-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three cases of acute nonlymphocytic leukemia with a Philadelphia chromosome (Ph) as a secondary abnormality are reported. The Ph was late-appearing in one patient and appeared as an additional anomaly in the other two patients. Fluorescence in situ hybridization studies of the first patient identified the presence of a minor BCR/ABL rearrangement. The findings of these cases support the conclusion that the Ph plays a role not only in leukemogenesis, but also in disease progression. An overview of the literature dealing with similar cases is also presented. (C) Elsevier Science Inc., 1998.

引用

页码：148 / 151

页数：4

共 35 条

[1] PHILADELPHIA-POSITIVE ACUTE-LEUKEMIA - CYTOGENETIC AND MOLECULAR ASPECTS [J].