Profiling DNA Methylomes from Microarray to Genome-Scale Sequencing

被引：41

作者：

Huang, Yi-Wen ^{[1
]}

Huang, Tim H. -M. ^{[1
]}

Wang, Li-Shu ^{[1
]}

机构：

[1] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2010年 / 9卷 / 02期

关键词：

DNA methylation; Microarray; Next-generation sequencing; CPG ISLAND METHYLATION; CYTOSINE METHYLATION; COLORECTAL-CANCER; BREAST-CANCER; HUMAN-CELLS; RESOLUTION; MAPS; WIDE; HYPERMETHYLATION; DIFFERENTIATION;

D O I：

10.1177/153303461000900203

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

DNA cytosine methylation is a central epigenetic modification which plays critical roles in cellular processes including genome regulation, development and disease. Here, we review current and emerging microarray and next-generation sequencing based technologies that enhance our knowledge of DNA methylation profiling. Each methodology has limitations and their unique applications, and combinations of several modalities may help build the entire methylome. With advances on next-generation sequencing technologies, it is now possible to globally map the DNA cytosine methylation at single-base resolution, providing new insights into the regulation and dynamics of DNA methylation in genomes.

引用

页码：139 / 147

页数：9

共 47 条

[1] Tumour class prediction and discovery by microarray-based DNA methylation analysis -: art. no. e21 [J].

Adorján, P ;

Distler, J ;

Lipscher, E ;

Model, F ;

Müller, J ;

Pelet, C ;

Braun, A ;

Florl, AR ;

Gütig, D ;

Grabs, G ;

Howe, A ;

Kursar, M ;

Lesche, R ;

Leu, E ;

Lewin, A ;

Maier, S ;

Müller, V ;

Otto, T ;

Scholz, C ;

Schulz, WA ;

Seifert, HH ;

Schwope, I ;

Ziebarth, H ;

Berlin, K ;

Piepenbrock, C ;

Olek, A .

NUCLEIC ACIDS RESEARCH, 2002, 30 (05) :e21

[2] Phase II study of concurrent administration of doxorubicin and docetaxel as first-line chemotherapy for metastatic breast cancer [J].

Aihara, T ;

Takatsuka, Y ;

Itoh, K ;

Sasaki, Y ;

Katsumata, N ;

Watanabe, T ;

Noguchi, S ;

Horikoshi, N ;

Tabei, T ;

Sonoo, H ;

Hiraki, S ;

Inaji, H .

ONCOLOGY, 2003, 64 (02) :124-130

[3] Hunting for the 5th base: Techniques for analyzing DNA methylation [J].

Ammerpohl, Ole ;

Martin-Subero, Jose I. ;

Richter, Julia ;

Vater, Inga ;

Siebert, Reiner .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2009, 1790 (09) :847-862

[4] Next-generation DNA sequencing techniques [J].

Ansorge, Wilhelm J. .

NEW BIOTECHNOLOGY, 2009, 25 (04) :195-203

[5] Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells [J].

Ball, Madeleine P. ;

Li, Jin Billy ;

Gao, Yuan ;

Lee, Je-Hyuk ;

LeProust, Emily M. ;

Park, In-Hyun ;

Xie, Bin ;

Daley, George Q. ;

Church, George M. .

NATURE BIOTECHNOLOGY, 2009, 27 (04) :361-368

[6] DNA hypermethylation in tumorigenesis - epigenetics joins genetics [J].

Baylin, SB ;

Herman, JG .

TRENDS IN GENETICS, 2000, 16 (04) :168-174

[7] High-throughput DNA methylation profiling using universal bead arrays [J].

Bibikova, M ;

Lin, ZW ;

Zhou, LX ;

Chudin, E ;

Garcia, EW ;

Wu, B ;

Doucet, D ;

Thomas, NJ ;

Wang, YH ;

Vollmer, E ;

Goldmann, T ;

Seifart, C ;

Jiang, W ;

Barker, DL ;

Chee, MS ;

Floros, J ;

Fan, JB .

GENOME RESEARCH, 2006, 16 (03) :383-393

[8] CPG-RICH ISLANDS AND THE FUNCTION OF DNA METHYLATION [J].

BIRD, AP .

NATURE, 1986, 321 (6067) :209-213

[9] Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver [J].

Brunner, Alayne L. ;

Johnson, David S. ;

Kim, Si Wan ;

Valouev, Anton ;

Reddy, Timothy E. ;

Neff, Norma F. ;

Anton, Elizabeth ;

Medina, Catherine ;

Nguyen, Loan ;

Chiao, Eric ;

Oyolu, Chuba B. ;

Schroth, Gary P. ;

Absher, Devin M. ;

Baker, Julie C. ;

Myers, Richard M. .

GENOME RESEARCH, 2009, 19 (06) :1044-1056

[10] Emerging methods for analysis of the cancer methylome [J].

Chang, Jer-Wei ;

Huang, Tim Hui-Ming ;

Wang, Yi-Ching .

PHARMACOGENOMICS, 2008, 9 (12) :1869-1878

← 1 2 3 4 5 →