NF-κB in cancer:: a marked target

被引：325

作者：

Lin, A

Karin, M

机构：

[1] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA

[2] Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2003年 / 13卷 / 02期

基金：

美国国家卫生研究院;

关键词：

cancer; NF-kappa B; transcription; anti-apoptosis; therapy;

D O I：

10.1016/S1044-579X(02)00128-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The imbalance between proliferation and programmed cell death (apoptosis) is one of the critical cellular events that lead to oncogenesis. While there is no doubt that uncontrolled cell proliferation is essential for the development of cancer, deregulation of apoptosis may play an equally important role in this process. Inhibition of apoptosis prevents the death of tumor cells with DNA damage either associated with carcinogenic initiation or cancer therapy. The transcription factor NF-kappaB is a key regulator in oncogenesis. By promoting proliferation and inhibiting apoptosis, NF-kappaB tips the balance between proliferation and apoptosis toward malignant growth in tumor cells. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：107 / 114

页数：8