NMR imaging investigations of drug delivery devices using a flow-through USP dissolution apparatus

被引：54

作者：

Fyfe, CA

Grondey, H

Blazek-Welsh, AI

Chopra, SK

Fahie, BJ

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[2] Glaxo Wellcome Inc, Pharmaceut Sci Div, Mississauga, ON L5N 6L4, Canada

来源：

JOURNAL OF CONTROLLED RELEASE | 2000年 / 68卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

controlled release; flow NMR imaging; USP Apparatus 4;

D O I：

10.1016/S0168-3659(00)00237-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A system for performing NMR imaging experiments on drug delivery devices within a how-through dissolution apparatus, USP Apparatus 4, has been developed. The system was used to image the physical changes that occur in solid dosage forms during dissolution in the Row-through apparatus. Simultaneous cumulative drug release measurements were also made. The NMR images obtained under these conditions and the drug release data provide a better understanding of the processes involved in the release of drugs from drug delivery systems based on diffusion, dissolution and osmosis mechanisms. (C) 2000 Elsevier Science B.V. All rights reserved.

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页码：73 / 83

页数：11

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