Using a 1 M Gd-chelate (gadobutrol) for total-body three-dimensional MR angiography:: preliminary experience

被引:48
作者
Goyen, M
Herborn, CU
Vogt, FM
Kröger, K
Verhagen, R
Yang, F
Bosk, S
Debatin, JF
Ruehm, SG
机构
[1] Univ Essen Gesamthsch, Dept Diagnost & Intervent Radiol, D-45122 Essen, Germany
[2] Univ Essen Gesamthsch, Dept Angiol, Essen, Germany
关键词
magnetic resonance angiography; Gd-based contrast agents; gadobutrol; whole-body MRA; gadopentetate dimeglumine;
D O I
10.1002/jmri.10302
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To determine whether higher concentrated gadolinium chelates are advantageous for the recently introduced concept of total-body magnetic resonance angiography (MRA), allowing whole-body coverage, extending from the carotid arteries to the runoff vessels, in merely 72 seconds. Materials and Methods: Total-body three-dimensional (3D) MRA using a 1 M Gd-chelate (gadobutrol, Gadovisto, Schering, Berlin, Germany) at a dosage of 0.2 mmol/kg body-weight (biphasic injection protocol: 1.3 mL/second and 0.7 mL/second) was performed on three healthy volunteers and ten consecutive patients with DSA-documented peripheral vascular disease. Separated by at least 72 hours, the three healthy volunteers also underwent the same MRA-protocol, using gadopentetate dimeglumine in equimolar dosages. Results: Compared to equimolar dosages, mean signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) values in the three volunteers were significantly higher (up to 32.5% for the arteries of the thighs and calves) using gadobutrol. In the ten patients, gadobutrol-based total-body MRA accurately assessed significant stenoses (luminal narrowing > 50%) with sensitivities and specificities of 96.2% (95% CI 0.83-0.97) and 95.7% (95% CI 0.84-0.96), respectively, compared to digital subtraction angiography. Conclusion: The MRA image quality for total-body MRA provided by the administration of gadobutrol is superior to that obtained following administration of an identical dose of gadopentetate dimeglumine, and therefore shows promise for use as a comprehensive single exam assessing the entire arterial system for the presence of atherosclerotic disease manifestations.
引用
收藏
页码:565 / 571
页数:7
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