Synthesis of functionalized oxacalix[4]arenes

被引：152

作者：

Katz, JL ^{[1
]}

Feldman, MB ^{[1
]}

Conry, RR ^{[1
]}

机构：

[1] Colby Coll, Dept Chem, Waterville, ME 04901 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 01期

关键词：

D O I：

10.1021/ol047840t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetranitrooxacalix[4]arenes are generated in high yield by the room-temperature SNAr reaction of 1,3-dihydroxybenzenes with 1,5-difluoro-2,4-dinitrobenzene. The reaction is tolerant to a range of functionality on the nucleophilic component, including hydroxyl-substitution at the 2- and 5-positions, which yields previously unknown 26,28- and 5,17-dihydroxyoxacalix[4]arenes.

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页码：91 / 94

页数：4

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