Why trypanosomes cause sleeoing sickness

被引：55

作者：

Lundkvist, GB ^{[1
]}

Kristensson, K

Bentivoglio, M

机构：

[1] Univ Virginia, Dept Biol, Charlottesville, VA 22904 USA

[2] Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden

[3] Univ Verona, Fac Med, Dept Morphol & Biomed Sci, I-37134 Verona, Italy

来源：

PHYSIOLOGY | 2004年 / 19卷

关键词：

D O I：

10.1152/physiol.00006.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

African trypanosomiasis or sleeping sickness is hallmarked by sleep and wakefulness disturbances. In contrast to other infections, there is no hypersomnia, but the sleep pattern is fragmented. This overview discusses that the causative agents, the parasites Trypanosoma brucei, target circumventricular organs in the brain, causing inflammatory responses in hypothalamic structures that may lead to dysfunctions in the circadian-timing and sleep-regulatory systems.

引用

页码：198 / 206

页数：9

共 75 条

[11] Narcolepsy in orexin knockout mice:: Molecular genetics of sleep regulation [J].

Chemelli, RM ;

Willie, JT ;

Sinton, CM ;

Elmquist, JK ;

Scammell, T ;

Lee, C ;

Richardson, JA ;

Williams, SC ;

Xiong, YM ;

Kisanuki, Y ;

Fitch, TE ;

Nakazato, M ;

Hammer, RE ;

Saper, CB ;

Yanagisawa, M .

CELL, 1999, 98 (04) :437-451

[12] Microglia activation in a model of sleep disorder:: an immunohistochemical study in the rat brain during Trypanosoma brucei infection [J].

Chianella, S ;

Semprevivo, M ;

Peng, ZC ;

Zaccheo, D ;

Bentivoglio, M ;

Grassi-Zucconi, G .

BRAIN RESEARCH, 1999, 832 (1-2) :54-62

[13] Afferents to the ventrolateral preoptic nucleus [J].

Chou, TC ;

Bjorkum, AA ;

Gaus, SE ;

Lu, J ;

Scammell, TE ;

Saper, CB .

JOURNAL OF NEUROSCIENCE, 2002, 22 (03) :977-990

[14] Plasma melatonin rhythm is maintained in human African trypanosomiasis [J].

Claustrat, B ;

Buguet, A ;

Geoffriau, M ;

Bogui, P ;

Mouanga, G ;

Stanghellini, A ;

Dumas, M .

NEUROENDOCRINOLOGY, 1998, 68 (01) :64-70

[15] TIMING OF HUMAN SLEEP - RECOVERY PROCESS GATED BY A CIRCADIAN PACEMAKER [J].

DAAN, S ;

BEERSMA, DGM ;

BORBELY, AA .

AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (02) :R161-R178

[16] CIRCADIAN-RHYTHMS IN NARCOLEPSY - STUDIES ON A 90 MINUTE DAY [J].

DANTZ, B ;

EDGAR, DM ;

DEMENT, WC .

ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1994, 90 (01) :24-35

[17] Sleep states alter activity of suprachiasmatic nucleus neurons [J].

Deboer, T ;

Vansteensel, MJ ;

Détári, L ;

Meijer, JH .

NATURE NEUROSCIENCE, 2003, 6 (10) :1086-1090

[18] Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristics [J].

Dijk, DJ ;

Duffy, JF .

ANNALS OF MEDICINE, 1999, 31 (02) :130-140

[19] SUPRACHIASMATIC NUCLEI LESIONS ELIMINATE CIRCADIAN TEMPERATURE AND SLEEP RHYTHMS IN THE RAT [J].

EASTMAN, CI ;

MISTLBERGER, RE ;

RECHTSCHAFFEN, A .

PHYSIOLOGY & BEHAVIOR, 1984, 32 (03) :357-368

[20] Sleep as a problem of localization [J].

Economo, CV .

JOURNAL OF NERVOUS AND MENTAL DISEASE, 1930, 71 :249-259

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