Quercetin: A functional dietary flavonoid with potential chemo-preventive properties in colorectal cancer

被引：193

作者：

Darband, Saber G. ^{[1
]}

Kaviani, Mojtaba ^{[2
]}

Yousefi, Bahman ^{[3
,4
]}

Sadighparvar, Shirin ^{[5
]}

Pakdel, Firouz G. ^{[5
]}

Attari, Javad A. ^{[6
]}

Mohebbi, Iraj ^{[7
]}

Naderi, Somayeh ^{[1
]}

Majidinia, Maryam ^{[8
]}

机构：

[1] Urmia Univ Med Sci, Danesh Pey Hadi Co, Hlth Technol Dev Ctr, Orumiyeh, Iran

[2] Acadia Univ, Sch Nutr & Dietet, Wolfville, NS, Canada

[3] Tabriz Univ Med Sci, Fac Med, Dept Clin Biochem & Lab Med, Tabriz, Iran

[4] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[5] Urmia Univ Med Sci, Neurophysiol Res Ctr, Orumiyeh, Iran

[6] Urmia Univ Med Sci, Dept Neurosurg, Orumiyeh, Iran

[7] Urmia Univ Med Sci, Occupat Med Ctr, Social Determinants Hlth Ctr, Orumiyeh, Iran

[8] Urmia Univ Med Sci, Solid Tumor Res Ctr, Orumiyeh, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2018年 / 233卷 / 09期

关键词：

apoptosis; colorectal cancer; flavonoids; quercetin; ABERRANT CRYPT FOCI; ESTROGEN-BINDING SITES; HUMAN COLON; CELL-LINE; MEDIATED APOPTOSIS; STEM-CELLS; MICROSATELLITE INSTABILITY; MOLECULAR CLASSIFICATION; G(2)/M ARREST; PROLIFERATION;

D O I：

10.1002/jcp.26595

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Recently, an intense attention has been paid to the application of natural compounds as a novel therapeutic strategy for cancer treatment. Quercetin, a natural flavonol present in many commonly consumed food items, is widely demonstrated to exert inhibitory effects on cancer progression through various mechanisms. Since there is a strong association with diets containing abundant vegetables, fruits, and grains, and significant decline in the risk of colon cancer, accumulation studies have focused on the anticancer potential of quercetin in colorectal cancer. Cell cycle arrest, increase in apoptosis, antioxidant replication, modulation of estrogen receptors, regulation of signaling pathways, inhibition of and metastasis and angiogenesis are among various mechanisms underlying the chemo-preventive effects of quercetin in colorectal cancer. This review covers various therapeutic interactions of Quercetin as to how targets cellular involved in cancer treatment.

引用

页码：6544 / 6560

页数：17

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