Dendritic cells in Leishmania infection

被引：54

作者：

Brandonisio, O

Spinelli, R

Pepe, M

机构：

[1] Univ Bari, Sch Med, Dept Internal Med Immunol & Infect Dis, Bari, Italy

[2] Univ Bari, Sch Med, Dept Human Anat & Histol, Bari, Italy

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 15期

关键词：

Leishmania; Leishmaniasis; dendritic cells; vaccine;

D O I：

10.1016/j.micinf.2004.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) are key elements of the immune system, which function as sentinel in the periphery and alert T lymphocytes about the type of invading antigen and address their polarisation, in order to mount an efficacious immune response. Leishmania spp. are parasitic protozoa which may cause severe disease in humans and domestic animals. In this work, the main studies concerning the role of DCs in Leishmania infection are reviewed, in both the murine and human models. In particular, the importance of the genetic status of the hosts and of the different Leishmania species in modulating DC-mediated immune response is examined. In addition, different approaches of DC-based vaccination against experimental leishmaniasis, which could have important future applications, are summarised. (C) 2004 Elsevier SAS. All rights reserved.

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页码：1402 / 1409

页数：8

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