Classifying human cancer by analysis of gene expression

被引：19

作者：

Hampton, GM

Frierson, HF

机构：

[1] Novartis Res Fdn, Genom Inst, San Diego, CA 92121 USA

[2] Univ Virginia, Dept Pathol, Charlottesville, VA 22908 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2003年 / 9卷 / 01期

关键词：

D O I：

10.1016/S1471-4914(02)00006-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With the development and application of,DNA microarrays, the expression of almost all human genes can now be systematically examined in human malignancies. This can lead to the identification of candidate molecular targets for therapeutic intervention and biomarkers for early detection of these diseases. However, perhaps the most exciting result to come from this research has been the demonstration that patterns of gene expression can distinguish between tumors of different anatomical origin, and define new subgroups of cancer with similar histological appearance, but distinct molecular profiles. Some of these new molecular subclasses of tumor appear to correlate with clinical behavior. If substantiated in larger studies, this might form a basis for stratifying patients so that they receive optimal therapeutic treatment and follow-up.

引用

页码：5 / 10

页数：6

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