Probing the active catalyst in product-accelerated proline-mediated reactions

被引：82

作者：

Iwamura, H ^{[1
]}

Wells, DH ^{[1
]}

Mathew, SP ^{[1
]}

Klussmann, M ^{[1
]}

Armstrong, A ^{[1
]}

Blackmond, DG ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 50期

关键词：

D O I：

10.1021/ja0444177

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new catalytic cycle involving only soluble proline complexes or adducts is proposed for the reactions in eq 1 based on kinetic observations and molecular modeling studies. This reaction pathway circumventing free proline and incorporating hydrogen-bonded reaction product helps to rationalize the observations of accelerating reaction rate in both the α-aminooxylation and α-amination reactions. Copyright © 2004 American Chemical Society.

引用

页码：16312 / 16313

页数：2

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