Gadolinium Oxide Ultranarrow Nanorods as Multimodal Contrast Agents for Optical and Magnetic Resonance Imaging

被引：146

作者：

Das, Gautom Kumar ^{[2
]}

Heng, Boon Chin ^{[3
]}

Ng, Sui-Choon ^{[2
]}

White, Tim ^{[3
]}

Loo, Joachim Say Chye ^{[3
]}

D'Silva, Loyola ^{[4
]}

Padmanabhan, Parasuraman ^{[4
]}

Bhakoo, Kishore K. ^{[4
]}

Selvan, Subramanian Tamil ^{[1
]}

Tan, Timothy Than Yang ^{[2
]}

机构：

[1] Inst Mat Res & Engn, Singapore 117602, Singapore

[2] Nanyang Technol Univ, Sch Chem & Biomed Engn, Div Chem & Biomol Engn, Singapore 637459, Singapore

[3] Nanyang Technol Univ, Sch Mat Sci & Engn, Div Mat Sci, Singapore 637459, Singapore

[4] Singapore Bioimaging Consortium, Translat Mol Imaging Grp, Singapore 138667, Singapore

来源：

LANGMUIR | 2010年 / 26卷 / 11期

关键词：

UP-CONVERSION; IN-VIVO; ORIENTED ATTACHMENT; QUANTUM DOTS; NANOPARTICLES; MRI; NANOCOMPOSITES; FLUORESCENCE; EFFICIENCY; SIZE;

D O I：

10.1021/la904751q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrate a simple synthetic strategy for the fabrication of single-phase rare earth (RE) doped gadolinium oxide (Gd2O3:RE where RE = terbium (Tb), ytterbium (Yb), and erbium (Er)) nanorods (NRs) as multimodal imaging probes. The NRs are ultranarrow and exhibit both emission and magnetic characteristics. The Tb-doped and Yb/Er-codoped Gd2O3 NRs exhibit down- and up-conversion fluorescence respectively, and also exhibit paramagnetism. Importantly, these codoped NRs possess excellent magnetic characteristics, as shown in their longitudinal relaxation time (TI) -weighted image contrast, which is closer to that of commercial Gadovist for magnetic resonance imaging (MRI) applications. This property opens up new avenues in the development of contrast agents.

引用

页码：8959 / 8965

页数：7

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