Non-homologous end-joining: bacteria join the chromosome breakdance

被引：56

作者：

Wilson, TE ^{[1
]}

Topper, LM ^{[1
]}

Palmbos, PL ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 02期

关键词：

D O I：

10.1016/S0968-0004(03)00005-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The repair of DNA double-strand breaks by nonhomologous end-joining (NHEJ) has long been thought to be restricted to eukaryotes. However, recent papers document the existence of operons encoding functional NHEJ complexes in some bacteria. These findings provide new evolutionary insights into the core biochemistry of this repair pathway, and suggest that one function driving the selection of NHEJ in bacteria, and perhaps eukaryotes, relates to prolonged periods of mitotic exit.

引用

页码：62 / 66

页数：5

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