The hair follicle-a stem cell zoo

被引：139

作者：

Jaks, Viljar

Kasper, Maria

Toftgard, Rune ^{[1
]}

机构：

[1] Karolinska Inst, Ctr Biosci, SE-14157 Huddinge, Sweden

来源：

EXPERIMENTAL CELL RESEARCH | 2010年 / 316卷 / 08期

基金：

瑞典研究理事会;

关键词：

Skin; Hair follicle; Stem cell markers; Lineage tracing; LABEL-RETAINING CELLS; POPULATION; DISTINCT; BULGE; SKIN; KERATINOCYTES; HOMEOSTASIS; EXPRESSION; RENEWAL; FATE;

D O I：

10.1016/j.yexcr.2010.03.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Recent studies on stem cells in the adult hair follicle (HF) have uncovered a veritable menagerie of exceptionally diverse and dynamic keratinocytes with stem cell properties located in distinct regions of the HF. Although endowed with specific functions during normal hair follicle maintenance, the majority of these cells can act as multipotent stem cells in stress situations, such as physical injury, which argues for an unanticipated degree of plasticity of these cells. This review provides an overview of the different epithelial stem cell populations, identified in the mouse HF, and their relationships with one another, and envisions possible cellular mechanisms underlying normal HF maintenance and skin regeneration. (C) 2010 Elsevier Inc. All rights reserved.

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页码：1422 / 1428

页数：7

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