The role of human and mouse Y chromosome genes in male infertility

被引:13
作者
Affara, NA
Mitchell, MJ
机构
[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England
[2] Fac Med, INSERM U491, Marseille, France
基金
英国生物技术与生命科学研究理事会;
关键词
Y chromosome; male fertility; deletions candidate genes;
D O I
10.1007/BF03343787
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
It was suggested by Ronald Fisher in 1931 that genes involved in benefit to the male (including spermatogenesis genes) would accumulate on the Y chromosome. The analysis of mouse Y chromosome deletions and the discovery of microdeletions of the human Y chromosome associated with diverse defective spermatogenic phenotypes has revealed the presence of intervals containing one or more genes controlling male germ cell differentiation. These intervals have been mapped, cloned and examined in detail for functional genes. This review discusses the genes mapping to critical spermatogenesis intervals and the evidence indicating which are the most likely candidates underlying Y-linked male infertility. (C) 2000, Editrice Kurtis.
引用
收藏
页码:630 / 645
页数:16
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