New insights into the structural organization of eukaryotic and prokaryotic cytoskeletons using cryo-electron tomography

被引：29

作者：

Kürner, J ^{[1
]}

Medalia, O ^{[1
]}

Linaroudis, AA ^{[1
]}

Baumeister, W ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Biol Struct, D-82152 Martinsried, Germany

来源：

EXPERIMENTAL CELL RESEARCH | 2004年 / 301卷 / 01期

关键词：

electron microscopy; macromolecular structure; actin; motility; spiroplasma;

D O I：

10.1016/j.yexcr.2004.08.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cryo-electron tomography (cryo-ET) is an emerging imaging technology that combines the potential of three-dimensional (3-D) imaging at molecular resolution (<5 nm) with a close-to-life preservation of the specimen. In conjunction with pattern recognition techniques, it enables us to map the molecular landscape inside cells. The application of cryo-ET to intact cells provides novel insights into the structure and the spatial organization of the cytoskeleton in prokaryotic and eukaryotic cells. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：38 / 42

页数：5

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