Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population

被引：45

作者：

Duell, Eric J. ^{[1
]}

Bonet, Catalina ^{[1
]}

Munoz, Xavier ^{[1
]}

Lujan-Barroso, Leila ^{[1
]}

Weiderpass, Elisabete ^{[2
,3
,4
,5
]}

Boutron-Ruault, Marie-Christine ^{[6
,7
,8
]}

Racine, Antoine ^{[6
,7
,8
]}

Severi, Gianluca ^{[9
,10
]}

Canzian, Federico ^{[11
]}

Rizzato, Cosmeri ^{[11
]}

Boeing, Heiner ^{[12
]}

Overvad, Kim ^{[13
]}

Tjonneland, Anne ^{[14
]}

Argueelles, Marcial ^{[15
]}

Sanchez-Cantalejo, Emilio ^{[16
,17
,18
]}

Chamosa, Saioa ^{[19
]}

Maria Huerta, Jose ^{[17
,20
]}

Barricarte, Aurelio ^{[17
,21
]}

Khaw, Kay-Tee ^{[22
]}

Wareham, Nick ^{[23
]}

Travis, Rutch C. ^{[24
]}

Trichopoulou, Antonia ^{[25
,26
]}

Trichopoulos, Dimitrios ^{[25
,26
,27
]}

Yiannakouris, Nikos ^{[25
,28
]}

Palli, Domenico ^{[29
]}

Agnoli, Claudia ^{[30
]}

Tumino, Rosario ^{[31
,32
]}

Naccarati, Alessio ^{[33
]}

Panico, Salvatore ^{[34
]}

Bueno-de-Mesquita, H. B ^{[35
,36
,37
]}

Siersema, Peter D. ^{[36
]}

Peeters, Petra H. M. ^{[38
,39
]}

Ohlsson, Bodil ^{[40
]}

Lindkvist, Bjorn ^{[41
]}

Johansson, Ingegerd ^{[4
,42
]}

Ye, Weimin ^{[4
,42
]}

Johansson, Matthias ^{[43
]}

Fenger, Claus ^{[44
]}

Riboli, Elio ^{[39
]}

Sala, Nuria ^{[1
]}

Gonzalez, Carlos A. ^{[1
]}

机构：

[1] Catalan Inst Oncol ICO IDIBELL, Canc Epidemiol Res Program, Unit Nutr Environm & Canc, Barcelona, Spain

[2] UiT Arctic Univ Norway, Dept Community Med, Fac Hlth Sci, Tromso, Norway

[3] Canc Registry Norway, Dept Res, Oslo, Norway

[4] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[5] Samfundet Folkhalsan, Helsinki, Finland

[6] Inst Gustave Roussy, INSERM, Ctr Res Epidemiol & Populat Hlth CESP, U1018,Nutr Hormones & Womens Hlth Team, F-94805 Villejuif, France

[7] Univ Paris 11, UMRS 1018, F-94805 Villejuif, France

[8] IGR, F-94805 Villejuif, France

[9] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic 3053, Australia

[10] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic 3010, Australia

[11] German Canc Res Ctr, Genom Epidemiol Grp, Heidelberg, Germany

[12] German Inst Human Nutr, Dept Epidemiol, Potsdam, Nuthetal, Germany

[13] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Aarhus, Denmark

[14] Danish Canc Soc, Res Ctr, Inst Canc Epidemiol Diet Canc & Hlth, Copenhagen, Denmark

[15] Publ Hlth Directorate, Asturias, Spain

[16] Escuela Andaluza Salud Publ, Granada, Spain

[17] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain

[18] Inst Invest Biosanitaria Granada Granada Ibs, Granada, Spain

[19] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[20] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[21] Navarre Publ Hlth Inst, Pamplona, Spain

[22] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

[23] Addenbrookes Hosp, MRC Epidemiol Unit, Inst Metab Sci, Cambridge, England

[24] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[25] Hellen Hlth Fdn, Athens, Greece

[26] Acad Athens, Bur Epidemiol Res, Athens, Greece

[27] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[28] Harokopio Univ Athens, Athens, Greece

[29] Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[30] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[31] Civic MP Arezzo Hosp, ASP Ragusa, Canc Registry, Ragusa, Italy

[32] Civic MP Arezzo Hosp, ASP Ragusa, Histopathol Unit, Ragusa, Italy

[33] HuGeF Human Genet Fdn, Torino Mol & Genet Epidemiol Unit, I-10126 Turin, Italy

[34] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[35] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[36] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[37] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[38] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[39] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England

[40] Lund Univ, Div Internal Med, Dept Clin Sci, Skane Univ Hosp, Lund, Sweden

[41] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Gothenburg, Sweden

[42] Umea Univ, Med Biobank, Umea, Sweden

[43] Int Agcy Res Canc IARC WHO, Lyon, France

[44] Odense Univ Hosp, Dept Clin Pathol, DK-5000 Odense, Denmark

来源：

INTERNATIONAL JOURNAL OF CANCER | 2015年 / 136卷 / 04期

基金：

英国医学研究理事会; 欧洲研究理事会;

关键词：

gastric cancer; blood group; ABO; FUT; genetic susceptibility; HELICOBACTER-PYLORI INFECTION; GENOME-WIDE ASSOCIATION; PANCREATIC-CANCER; LEWIS ANTIGENS; GROUP ALLELES; EXPRESSION; VITAMIN-B-12; VARIANTS; GENOTYPE; MUCOSA;

D O I：

10.1002/ijc.29034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

ABO blood serotype A is known to be associated with risk of gastric cancer (GC), but little is known how ABO alleles and the fucosyltransferase (FUT) enzymes and genes which are involved in Lewis antigen formation [and in Helicobacter pylori (H. pylori) binding and pathogenicity] may be related to GC risk in a European population. The authors conducted an investigation of 32 variants at ABO and FUT1-7 loci and GC risk in a case-control study of 365 cases and 1,284 controls nested within the EPIC cohort (the EPIC-Eurgast study). Four variants (including rs505922) in ABO, and allelic blood group A (AO+AA, odds ratio=1.84, 95%CI=1.20-2.80) were associated with diffuse-type GC; however, conditional models with other ABO variants indicated that the associations were largely due to allelic blood group A. One variant in FUT5 was also associated with diffuse-type GC, and four variants (and haplotypes) in FUT2 (Se), FUT3 (Le) and FUT6 with intestinal-type GC. Further, one variant in ABO, two in FUT3 and two in FUT6 were associated with H. pylori infection status in controls, and two of these (in FUT3 and FUT6) were weakly associated with intestinal-type GC risk. None of the individual variants surpassed a Bonferroni corrected p-value cutoff of 0.0016; however, after a gene-based permutation test, two loci [FUT3(Le)/FUT5/FUT6 and FUT2(Se)] were significantly associated with diffuse- and intestinal-type GC, respectively. Replication and functional studies are therefore recommended to clarify the role of ABO and FUT alleles in H. pylori infection and subtype-specific gastric carcinogenesis. What's New? Blood type A indicates a higher risk of gastric cancer, but why? This study examined the relationship between blood group genes and cancer. The authors investigated 32 variants among not only the ABO alleles, but also including the genes involved in producing the Lewis blood group antigens. They confirmed blood group A as a risk factor for diffuse-type gastric cancer, and also detected an association between certain Lewis antigen alleles and intestinal-type gastric cancer. Interestingly, these alleles also popped up among controls who harbored H. pylori infection. These associations certainly warrant further investigation into their role in gastric cancer.

引用

页码：880 / 893

页数：14

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