Dopamine Receptor D1/D5 Gene Expression in the Medial Prefrontal Cortex Predicts Impulsive Choice in Rats

被引：81

作者：

Loos, Maarten ^{[1
]}

Pattij, Tommy ^{[2
]}

Janssen, Mieke C. W. ^{[2
]}

Counotte, Danielle S. ^{[1
]}

Schoffelmeer, Anton N. M. ^{[2
]}

Smit, August B. ^{[1
]}

Spijker, Sabine ^{[1
]}

van Gaalen, Marcel M. ^{[2
]}

机构：

[1] Vrije Univ Amsterdam, Dept Mol & Cellular Neurobiol, Ctr Neurogenom & Cognit Res, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Dept Anat & Neurosci, Ctr Neurogenom & Cognit Res, NL-1081 HV Amsterdam, Netherlands

来源：

CEREBRAL CORTEX | 2010年 / 20卷 / 05期

关键词：

caly; Drd1; Drd5; impulsive decision making; real-time quantitative polymerase chain reaction; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; CATECHOL-O-METHYLTRANSFERASE; ORBITOFRONTAL CORTEX; DELAY AVERSION; MODULATION; ADHD; ASSOCIATION; CALCYON; MEMORY;

D O I：

10.1093/cercor/bhp167

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A neuropsychological hallmark of attention deficit/hyperactivity disorder (ADHD) is the reduced ability to tolerate delay of reinforcement, leading to impulsive choice. Genetic association studies have implicated several genes involved in dopaminergic neurotransmission in ADHD. In this study, we investigated whether differences in the expression level of these dopamine-related genes of rats predict the individual level of impulsive choice. Among all frontostriatal brain regions tested, only in the medial prefrontal cortex (mPFC), we observed significant positive correlations between impulsive choice and transcript levels of the dopamine receptor D-1, the dopamine receptor D-5 and calcyon. Local mPFC infusions of the D-1/D-5 receptor antagonist SCH 23390 and agonist SKF 38393 resulted in increased impulsive choice, in agreement with the idea that endogenous receptor D-1/D-5 stimulation in the mPFC promotes the choice of large delayed rewards. Together, these data indicate that this class of dopamine receptors in the mPFC plays a pivotal role in impulsive choice, and aberrancies thereof might contribute to ADHD symptomatology.

引用

页码：1064 / 1070

页数：7

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