Apoptosis and necrosis in toxicology: A continuum or distinct modes of cell death?

被引:153
作者
Raffray, M [1 ]
Cohen, GM [1 ]
机构
[1] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England
关键词
apoptosis; necrosis; toxicology; toxicant; molecular pathway;
D O I
10.1016/S0163-7258(97)00037-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Mounting evidence indicates that apoptosis rather than necrosis predominates in many cytolethal toxic injuries. Associated cell death models of apoptosis and necrosis are either: (1) totally separate death modes, (2) a continuum whereby they are extremes of biochemically overlapping death pathways, or (3) essentially distinct processes with only limited molecular and cell biology overlap. We conclude that the current balance of evidence favours the third of these options. The established axiom that, even when considering the same toxicant, injury amplitude (dose) is a primary determinant of whether cells die via active cell death (apoptosis) or failure of homeostasis (necrosis) remains valid. Tissue selectivity of toxicants can stem from the apoptotic or necrotic thresholds at which different cells die, as well as targeting factors such as toxicokinetics, receptor recognition, bioactivation, and cell-specific lesions. (C) 1997 Elsevier Science Inc.
引用
收藏
页码:153 / 177
页数:25
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