General functionalization route for cell adhesion on non-wetting surfaces

被引：630

作者：

Ku, Sook Hee ^{[1
]}

Ryu, Jungki ^{[1
]}

Hong, Seon Ki ^{[2
,3
]}

Lee, Haeshin ^{[2
,3
]}

Park, Chan Beum ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Mat Sci & Engn, Inst BioCentury, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

[3] Korea Adv Inst Sci & Technol, Grad Sch Nanosci & Technol, Inst BioCentury, Taejon 305701, South Korea

来源：

BIOMATERIALS | 2010年 / 31卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

Cell adhesion; Non-wetting surfaces; Mussel adhesives; Poly(dopamine); Surface modification; PROTEIN; ATTACHMENT; CHEMISTRY; SCAFFOLD; DESIGN; FILMS;

D O I：

10.1016/j.biomaterials.2009.12.020

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We present a versatile route for promoting cell adhesion and viability on various non-wetting Surfaces. inspired by mussel adhesion mechanism. The oxidative polymerization of dopamine, a small designer molecule of the DOPA-K motif found in mussels, results in the formation of a poly(dopamine) ad-layer on any material Surface We found that the poly(dopamine) coating can promote cell adhesion oil any type of material surfaces including the well-known anti-adhesive Substrate, poly(tetrafluoroethylene) According to our results. mammalian cells well adhered and underwent general cell adhesion processes (i e. attachment to Substrate. spreading, and cytoskeleton development) oil poly(dopamine)-modified surfaces, while they barely adhered and spread on unmodified non-wetting surfaces The mussel-inspired Surface functionalization strategy is extremely useful because it does not require the time-consuming synthesis of complex linkers and the process is solvent-free and non-toxic Therefore, it call be a powerful route for converting a variety of bioinert Substrates into bioactive ones (C) 2009 Elsevier Ltd All rights reserved

引用

页码：2535 / 2541

页数：7

共 35 条

[1] Osteoblast adhesion on biomaterials [J].

Anselme, K .

BIOMATERIALS, 2000, 21 (07) :667-681

[2] Surface behaviour of biomaterials:: The theta surface for biocompatibility [J].

Baier, Robert Edward .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2006, 17 (11) :1057-1062

[3] Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function [J].

Bettinger, Christopher J. ;

Langer, Robert ;

Borenstein, Jeffrey T. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (30) :5406-5415

[4] Biocompatibility of biodegradable semiconducting melanin films for nerve tissue engineering [J].

Bettinger, Christopher J. ;

Bruggeman, Post P. ;

Misra, Asish ;

Borenstein, Jeffrey T. ;

Langer, Robert .

BIOMATERIALS, 2009, 30 (17) :3050-3057

[5] Biocompatible polymer materials: Role of protein-surface interactions [J].

Chen, Hong ;

Yuan, Lin ;

Song, Wei ;

Wu, Zhongkui ;

Li, Dan .

PROGRESS IN POLYMER SCIENCE, 2008, 33 (11) :1059-1087

[6]

Dee KC, 1998, J BIOMED MATER RES, V40, P371, DOI 10.1002/(SICI)1097-4636(19980605)40:3<371::AID-JBM5>3.3.CO

[7]

2-G

[8] High-yield activation of scaffold polymer surfaces to attach cell adhesion molecules [J].

Dennes, T. Joseph ;

Hunt, Geoffrey C. ;

Schwarzbauer, Jean E. ;

Schwartz, Jeffrey .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (01) :93-97

[9] Effect of hole size on the incorporation of C60 molecules inside single-wall carbon nanohorns and their release [J].

Fan, Jing ;

Yuge, Ryota ;

Maigne, Alan ;

Miyawaki, Jin ;

Iijima, Sumio ;

Yudasaka, Masako .

CARBON, 2008, 46 (13) :1792-1794

[10]

GRINNELL F, 1982, J BIOL CHEM, V257, P4888

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