Magneto-fluorescent core-shell supernanoparticles

被引：236

作者：

Chen, Ou ^{[1
]}

Riedemann, Lars ^{[2
,3
]}

Etoc, Fred ^{[4
]}

Herrmann, Hendrik ^{[5
,6
]}

Coppey, Mathieu ^{[4
]}

Barch, Mariya ^{[7
]}

Farrar, Christian T. ^{[8
]}

Zhao, Jing ^{[1
]}

Bruns, Oliver T. ^{[1
]}

Wei, He ^{[1
]}

Guo, Peng ^{[9
]}

Cui, Jian ^{[1
]}

Jensen, Russ ^{[1
]}

Chen, Yue ^{[1
]}

Harris, Daniel K. ^{[1
]}

Cordero, Jose M. ^{[1
]}

Wang, Zhongwu ^{[10
]}

Jasanoff, Alan ^{[7
,11
,12
]}

Fukumura, Dai ^{[2
,3
]}

Reimer, Rudolph ^{[5
]}

Dahan, Maxime ^{[4
]}

Jain, Rakesh K. ^{[2
,3
]}

Bawendi, Moungi G. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

[2] Massachusetts Gen Hosp, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA 02114 USA

[4] Inst Curie, CNRS, Lab Phys Chim Curie, UMR168, F-75248 Paris, France

[5] Heinrich Pette Inst, D-20251 Hamburg, Germany

[6] Bernhard Nocht Inst Trop Med, D-20359 Hamburg, Germany

[7] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[8] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[9] Harvard Univ, Sch Med, Childrens Hosp Boston, Vasc Biol Program, Boston, MA 02115 USA

[10] Cornell Univ, Wilson Lab, CHESS, Ithaca, NY 14853 USA

[11] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA

[12] MIT, Dept Nucl Sci & Engn, Cambridge, MA 02139 USA

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

基金：

美国国家科学基金会;

关键词：

ONE-POT SYNTHESIS; QUANTUM DOTS; DRUG-DELIVERY; THERANOSTIC APPLICATIONS; HYBRID NANOPARTICLES; NANOCRYSTALS; RESONANCE; NANOCOMPOSITES; SUPERLATTICES; NANOMEDICINE;

D O I：

10.1038/ncomms6093

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magnetofluorescent nanomaterials that simultaneously exhibit uniform and tunable sizes, high magnetic content loading, maximized fluorophore coverage at the surface and a versatile surface functionality has proven challenging. Here we report a simple approach for co-assembling magnetic nanoparticles with fluorescent quantum dots to form colloidal magneto-fluorescent supernanoparticles. Importantly, these supernanoparticles exhibit a superstructure consisting of a close-packed magnetic nanoparticle 'core', which is fully surrounded by a 'shell' of fluorescent quantum dots. A thin layer of silica coating provides high colloidal stability and biocompatibility, and a versatile surface functionality. We demonstrate that after surface pegylation, these silica-coated magneto-fluorescent supernanoparticles can be magnetically manipulated inside living cells while being optically tracked. Moreover, our silica-coated magneto-fluorescent supernanoparticles can also serve as an in vivo multi-photon and magnetic resonance dual-modal imaging probe.

引用

页数：8

共 51 条

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