Rapid, transient induction of ER stress in the liver and kidney after acute exposure to heavy metal: Evidence from transgenic sensor mice

被引：57

作者：

Hiramatsu, Nobuhiko

Kasai, Ayumi

Du, Shuqi

Takeda, Masayuki

Hayakawa, Kunihiro

Okamura, Maro

Yao, Jian

Kitamura, Masanori ^{[1
]}

机构：

[1] Univ Yamanashi, Dept Mol Signaling, Interdisciplinary Grad Sch Med & Engn, Yamanashi 4093898, Japan

[2] Univ Yamanashi, Dept Urol, Interdisciplinary Grad Sch Med & Engn, Yamanashi 4093898, Japan

[3] China Med Univ, Dept Urol, Hosp 1, Shenyang 110001, Peoples R China

来源：

FEBS LETTERS | 2007年 / 581卷 / 10期

关键词：

endoplasmic reticulum (ER) stress; ER stress-responsive; alkaline phosphatase (ES-TRAP); transgenic mouse; heavy metal; biosensor;

D O I：

10.1016/j.febslet.2007.04.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endoplasmic reticulum (ER) stress-responsive alkaline phosphatase (ES-TRAP) serves as a sensitive indicator for ER stress. In response to heavy metals including cadmium, nickel and cobalt, hepatocytes and renal tubular cells expressing ESTRAP exhibited ER stress and decreased ES-TRAP activity. In ES-TRAP transgenic mice, acute exposure to cadmium showed rapid, transient decreases in the activity of serum ESTRAP. It was inversely correlated with the induction of endogenous ER stress markers in the liver and kidney. Our result provides first evidence for the acute, reversible induction of ER stress in vivo after exposure to heavy metal. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2055 / 2059

页数：5

共 16 条

[1] Manganese induces endoplasmic reticulum (ER) stress and activates multiple caspases in nigral dopaminergic neuronal cells, SN4741 [J].

Chun, HS ;

Lee, H ;

Son, JH .

NEUROSCIENCE LETTERS, 2001, 316 (01) :5-8

[2] Alkaline phosphatase vs luciferase as secreted reporter molecules in vivo [J].

Hiramatsu, N ;

Kasai, A ;

Meng, YM ;

Hayakawa, K ;

Yao, J ;

Kitamura, M .

ANALYTICAL BIOCHEMISTRY, 2005, 339 (02) :249-256

[3] Real-time detection and continuous monitoring of ER stress in vitro and in vivo by ES-TRAP:: evidence for systemic, transient ER stress during endotoxemia [J].

Hiramatsu, Nobuhiko ;

Kasai, Ayumi ;

Hayakawa, Kunihiro ;

Yao, Jian ;

Kitamura, Masanori .

NUCLEIC ACIDS RESEARCH, 2006, 34 (13)

[4]

*IPCS INT PROGR CH, 1992, 134 IPCS ENV HLTH CR

[5] A transgenic mouse model for monitoring endoplasmic reticulum stress [J].

Iwawaki, T ;

Akai, R ;

Kohno, K ;

Miura, M .

NATURE MEDICINE, 2004, 10 (01) :98-102

[6] High levels of dioxin-like potential in cigarette smoke evidenced by in vitro and in vivo biosensing [J].

Kasai, Ayumi ;

Hiramatsu, Nobuhiko ;

Hayakawa, Kunihiro ;

Yao, Jian ;

Maeda, Shuichiro ;

Kitamura, Masanori .

CANCER RESEARCH, 2006, 66 (14) :7143-7150

[7] Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations [J].

Katayama, T ;

Imaizumi, K ;

Honda, A ;

Yoneda, T ;

Kudo, T ;

Takeda, M ;

Mori, K ;

Rozmahel, R ;

Fraser, P ;

St George-Hyslop, P ;

Tohyama, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (46) :43446-43454

[8] Orchestrating the unfolded protein response in health and disease [J].

Kaufman, RJ .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (10) :1389-1398

[9] The glucose-regulated proteins: stress induction and clinical applications [J].

Lee, AS .

TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (08) :504-510

[10] Cadmium accumulation in liver and kidney of mice exposed to the same weekly cadmium dose continuously or once a week [J].

Lind, Y ;

Engman, J ;

Jorhem, L ;

Glynn, AW .

FOOD AND CHEMICAL TOXICOLOGY, 1997, 35 (09) :891-895

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