Carbohydrate recognition in water by a tricyclic polyamide receptor

被引:143
作者
Klein, E [1 ]
Crump, MP [1 ]
Davis, AP [1 ]
机构
[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England
关键词
carbohydrates; hydrophobic effect; molecular recognition; receptors; supramolecular chemistry;
D O I
10.1002/anie.200461409
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A sweet center: Most carbohydrates are supremely comfortable in water. Can they be tempted to leave? Yes, if their new home satisfies all their needs. The watersoluble receptor 1 (R = polycarboxylate) provides hydrophobic surfaces (purple) for CH groups and amide groups (red) for polar substituents. Equatorial substitution is especially well accommodated, and the system duly favors β-glucosyl (2).
引用
收藏
页码:298 / 302
页数:5
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