Carbohydrate recognition in water by a tricyclic polyamide receptor

被引：143

作者：

Klein, E ^{[1
]}

Crump, MP ^{[1
]}

Davis, AP ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 02期

关键词：

carbohydrates; hydrophobic effect; molecular recognition; receptors; supramolecular chemistry;

D O I：

10.1002/anie.200461409

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A sweet center: Most carbohydrates are supremely comfortable in water. Can they be tempted to leave? Yes, if their new home satisfies all their needs. The watersoluble receptor 1 (R = polycarboxylate) provides hydrophobic surfaces (purple) for CH groups and amide groups (red) for polar substituents. Equatorial substitution is especially well accommodated, and the system duly favors β-glucosyl (2).

引用

页码：298 / 302

页数：5

共 39 条

[11] Editorial overview: Progress at the frontiers of structural glycobiology [J].