Toll-like receptors in the pathogenesis of human disease

被引：694

作者：

Cook, DN ^{[1
]}

Pisetsky, DS

Schwartz, DA

机构：

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[2] Vet Adm Med Ctr, Durham, NC 27710 USA

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 10期

关键词：

D O I：

10.1038/ni1116

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These studies have shown that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma. As this body of data grows, it will provide new insights into disease pathogenesis as well as valuable information on the merits of various therapeutic options.

引用

页码：975 / 979

页数：5

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